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Alternatively, devices based on solution process small molecules suffer from the need of these solubilizing groups which reduces the crystallinity and T g of the films.
And "electronic noses," an array of dyes, and other sensors that change color or chemical properties when they react with certain molecules suffer from the same drawback.
Regulator molecules including growth factors and signaling molecules are major factors with the key ability to regulate stem cell behaviors, However, naturally occurring regulator molecules suffer from short circulation half-life and fast degradation rate under in vivo circumstances.
When new molecules suffer from drawbacks of first pass metabolism or have shorter plasma half-life than alternative delivery, routes such as transdermal can be considered.
Many newly developed active pharmaceutical ingredients (APIs) or drug molecules suffer from low aqueous solubility and belong therefore to the Biopharmaceutics Classification System (BCS) class II or IV.
Large quantities of newly developed pharmacologically active molecules suffer from poor water solubility resulting in insufficient biopharmaceutical properties since drug solubility and dissolution rates are frequently the limiting steps in intestinal drug absorption.
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Even though intact mAbs showed promise in E-selectin targeting and RA imaging, they are large molecules and suffer from slow blood clearance.
Such molecules may suffer from the same drawbacks as RNA with respect to prebiotic chemistry, such as the difficulty of selective sugar synthesis, sugar instability, and the difficulty of nucleoside formation.
However, these organic molecules usually suffer from poor water-solubility and poor biocompatibility, as well as limited membrane-permeability, obstacles which strictly limit their intracellular applications.
For example, the task of tracking GFP protein molecules will suffer from multiple targets with almost identical appearances moving around a noisy background.
Furthermore, the published studies of multiple-molecule searches suffer from critical weaknesses: reliance on proprietary data, poorly characterized background databases, and non-standardized performance metrics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com