Sentence examples for molecules specifically targeted from inspiring English sources

It is proposed that PTC limits SMO signaling by transporting small endogenous molecules specifically targeted to SMO.

As discussed previously, the MEK inhibitor UO126 is a candidate inhibitor of IGF1 that could be tested in combination with an autophagy inhibitor such as HCQ as a proof-of-concept prior to the development of molecules specifically targeted to IGF1.

Drug companies are now putting an effort into the development of new molecules specifically targeting the kinesin family.

OA chondrocytes were transfected with pre-miRNA and anti-miRNA molecules specifically targeting the human miR-140 and miR-27a (45 nM final concentration; Applied Biosystems) in DMEM and the HiPerfect Transfection Reagent (3% final concentration; Qiagen).

Atu027 is a lipoplexed siRNA molecule specifically targeting the expression of protein kinase N3, which has been identified as a downstream effector of the phosphoinositol-3-kinase signaling pathway [ 29].

Gefitinib is a small-molecule agent specifically targeted to inhibit the epidermal growth factor receptor tyrosine kinase (EGFR-TK).

To confirm that the IR-sensitive phenotype of SPLhi cells is specifically attributed to SPL overexpression and not an acquired genetic modification associated with stable transformation, SPL overexpression was reversed by lentiviral expression of a shRNA molecule that specifically targeted human SPL.

One interesting approach to delineate the distinct roles of metabolic regulatory function and the complex I assembly function of NDUFS3 (and other pertinent complex I subunits) will be by means of rationally-designed small molecule probes specifically targeted to NDUFS3 assembly sites.

The aim of the current study was to determine whether small inhibitory RNA (SiRNA) molecules could specifically target canine KIT mRNA for knock-down.

We believe the structural clues identified in this study can be used to identify novel peptidometics and small molecules that specifically target ER dimer interface generating a new breed of anti-cancer agents.

Finally, we summarize recent advances in the design and application of a number of molecules that specifically target individual RhoGTPases or their regulators or effectors, and discuss their potential for cancer therapy.