To eliminate hepatitis C virus (HCV) from infected hepatocytes, we generated two therapeutic molecules specifically activated in cells infected with HCV.
The former tried to differentiate MSC using molecules specifically involved in neural development (growth factors, neurotrophins, cytokines and retinoic acid) [6], while the latter proposed that neural induction could be performed simply by the addition of specific chemical compounds to the culture medium (β-mercaptoethanol [BME], dimethyl sulfoxide [DMSO] and butylated hydroxyanizole [BHA]) [9].
The authors directly address the dichotomy between the benefits and harms of death effector molecules, specifically caspases, in inflammatory diseases, infection, neurodegenerative diseases and cancer.
Recent studies on monogenetic inherited nephrotic syndrome (NS) and primary NS have revealed many protein molecules specifically expressed in podocytes, such as nephrin, CD2AP, podocin, and TRPC [ 5– 7].
Single-crystal X-ray diffraction had been previously used to determine the positions of gas molecules, specifically CO2, in a dynamically porous one-dimensional coordination polymer under a sealed gaseous atmosphere (Takamizawa et al., 2003 ▶), but not on a three-dimensional framework with such large voids and with the potential for many crystallographically independent adsorption sites.
First, to identify the molecules specifically upregulated in TAM-like THP-1 cells, we performed a cDNA microarray analysis using RNAs from THP-1 stimulated with 200 nmol/L TPA or with 200 nmol/L TPA followed by 50% TE-8CM (Fig. 1A).
But in fact a single dose of nicotine has effects on the brain that can last as long as a month, and the nicotine obtained from just one or two puffs on a cigarette will occupy half of the brain's nicotinic receptors, the molecules specifically sought by nicotine in tobacco addiction.
The aim of this study was to identify molecules specifically recognized by serum autoantibodies in patients with Behçet's disease and to evaluate their diagnostic value.
To identify the molecules specifically up- and downregulated in NF-25 fibroblasts, we performed a cDNA microarray analysis using total RNAs from NF-25 fibroblasts cultured in the presence or absence of HSC-39 cells.
By injecting into the body cavity long double-stranded RNA (dsRNA) molecules, specifically directed against genes uniquely expressed in the midgut and salivary glands, we were able to significantly inhibit the expression of the targeted mRNA in the different organs.
