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The resulting dendritic molecules showed a range of solubilities in chloroform fairly affected by the dendritic backbone structures.
Some of the molecules showed a promising anticonvulsant profile as selective anti-MES drugs, being active at low concentrations (30 mg/kg).
The optimised multiplex assay detecting HSV1, HSV2 and VZV using 103 IPC molecules showed a performance and sensitivity comparable to that of the individual assays.
All tested molecules showed a concentration-dependent enhancement in fibronectin-mediated adhesion of K562 and SK-MEL-24 cells; in particular 1, expressed a higher affinity towards α5β1 integrin (EC50 of 12 nM) and 2 was more selective for integrin αvβ3 (EC50 of 11 nM).
The loading and release kinetics of both molecules showed a clear pH and temperature dependent profile.
All molecules showed a higher CSF concentration in S2 patients compared to S1. IgM, MMP-9 and CXCL13 showed the highest fold increase (S2/S1 concentration ratio of 68, 12 and 187, respectively).
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These molecules show a promising potential as theranostic agents for the diagnosis and therapy of AD.
Sorption experiments in solutions with high concentrations of corresponding organic molecules show a high adsorption capacity.
For the first time, researchers have managed to sequence proteins from the long-extinct creature, leading them to the discovery that many of the molecules show a remarkable similarity to those of the humble chicken.
Proteolysis measurements on thousands of tethered collagen molecules show a load-enhanced trypsin sensitivity, indicating destabilization of the triple helix.
The optimized geometries indicate that these molecules show a distinctly nonplanar configuration of the imidazoline and oxazoline moieties.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com