An ideal single-molecule probe should exhibit good brightness, uninterrupted emission, resistance to photobleaching, and minimal spectral overlap with cellular autofluorescence.
Instead of trying to find a new molecule in a database that should exhibit the same P x,y) characteristics, we side step this requirement (which may be difficult to guarantee) and we build a new drug candidate using only the information that is strictly contained in the training set itself.
It was extrapolated that, considering that the LE is kept constant during the fragment evolution, a good starting point should exhibit a LE of 0.3 in order to yield a molecule of 500 g.mol−1 with a IC50<10 nM [39].
To search for a CAR-regulated signal molecule that may be involved in promotion of HCC development, we hypothesized that this factor should exhibit CAR-dependent induction by nongenotoxic carcinogens long before the liver develops tumors and should be further induced in tumor tissues.
Most insects should exhibit behaviour involving approach, identification, and copulation.
In fact, that's what a case study should exhibit.
Tilted systems, however, should exhibit increasing difference in energy output.
These camps should be loosely connected, and they should exhibit a higher density internally.
You should exhibit discretion.
Thus, vicriviroc should exhibit limited transplacental diffusion.
