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On the functional side, these molecules respond to the binding of a neurotransmitter (glycine, GABA, acetylcholine or 5HT3) in the extracellular domain (ECD) by opening their ionotropic pore in the transmembrane domain (TMD).
Molecules respond to a range of stimuli, including force and light.
To attain the greatest effect, Mikkelsen's team needed to tune the gap's resonant frequency to match the color of light that the molecules respond to.
To determine if proximal signaling molecules respond to virus, we evaluated phosphorylation of TLR signaling members, IRAK-1 (specific for the MyD88-dependent pathway, Swiss-Prot ID: P51617) and IRF-3 (member of both pathways).
To understand how RNA molecules respond to perturbations, we measured two types of robustness.
The situation is similar in signal transduction networks; molecules respond to signals rather than turn over.
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To investigate the modulated molecules responding to low temperature, moreover, we attempted the proteomics to profile the hepatic proteome in Xenopus laevis after exposure to low temperature [ 80].
Taken together, these results show that the CRRL strategy can be used to cyclize molecules, conjugate to other molecules, and release molecules responding to environmental redox stimuli with real-time characterization by a noninvasive straightforward UV vis absorption spectroscopy technique.
A number of different signalling molecules released by astrocytes are likely to be under the control of the transcription factor NF-κB, a key molecule responding to both redox and inflammatory stimuli [20].
Calculated from 2D similarity and compound potency, it distinguishes between three principal types of SARs that are essentially characterized by the way biological activity of small molecules responds to chemical modifications.
In gilthead seabream, the expression of several ECM-related molecules responds to pro-inflammatory stimuli in immune competent tissues [ 39].
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