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In the present article we review all the recent small molecules reported to inhibit recombinant HIV-1 IN under these heads.
In this respect structural details are given concerning water molecules reported to be stabilized between the active ligand and the protein receptor.
To this aim, we defined a pharmacology training set of 25 compounds containing 3 small molecules reported to directly engage AR as antagonists, and a range of compound classes targeting AR co-regulator proteins.
There are a few drug molecules reported to interact with (and inhibit) the FOXM1 DNA binding domain (FOXM1-BD), causing downregulation of protein expression and cancer cell proliferation inhibition.
To identify the protein sensing cortical branched actin, we screened all molecules reported to recognise the Arp2/3 complex in the context of the actin branch, namely cortactin, GMFs and type I coronins, which all regulate the stability of the branched junction10,11 (Fig. 2a).
Furthermore, the large number of plasma membrane-resident ion channels and signaling molecules reported to interact with the S1R was puzzling given the very limited presence of S1R in the plasma membrane.
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In one specific example, the TNF4-opt peptide developed with this algorithm is one of the highest affinity TNF-α binding peptides/small-molecules reported to-date [28] [30], [41].
Furthermore, VE-cadherin, an endothelial-specific adherens junction molecule reported to connect lymphatic endothelial cells in lymphatic vessels [26], was expressed on host as well as on bone marrow-derived TLEC, further demonstrating a functional integration of BMDC into tumor lymphatic vasculature (Figure 3).
nSMase2 is the first molecule reported to be related to miRNA secretion into exosomes.
This is the strongest reversible bond involving a biological molecule reported to date.
- Finally, metformin is another interesting small molecule reported to modulate autophagy both positively and negatively.
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