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Glycosylating complex molecules remains a major synthetic challenge, making it hard to explore carbohydrate diversity in biologically active glycosylated natural products and their derivatives.
The atmospheric mixture used, Wells claims, is now known not to be similar to the Earth's atmosphere at the time life was thought to form; therefore, the experiment is irrelevant, and the origin of organic molecules remains a mystery.
Predicting peptide binding for MHC class II molecules remains a challenging problem [27].
In the genome era, characterizing the structure and the function of RNA molecules remains a major challenge.
Neu5Gc incorporation in human molecules remains a complex and unknown process.
Although purified channels have been used to evolve new toxins by phage display, the availability of high quality target molecules remains a major impediment.
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Understanding the nature of interactions between ion channels and blocking molecules remains an important area of inquiry.
The development of structure and sequence-specific nucleic acid binding molecules remains an important challenge in chemical biology.
There is evidence to support an association between wheat intake and T1D, but the basis of this association and the link to specific molecules remains an open question [ 7- 9].
AFSSAPS had pulled the drug from the market in early June on the suspicion that it causes bladder cancer, but EMA says that despite "a small increased risk," the molecule remains "a valid treatment option for certain patients with type 2 diabetes".
However, general fragmentation prediction of arbitrary small molecule remains an active field of research, due to the structural diversity of metabolites and the complexity of their fragmentation patterns.
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