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These small molecules reduce the number of protein aggregates and cytotoxicity, both in cellular and Drosophila models of neurodegenerative disease [ 212, 213].
Verneris et al. [23] proposed that because the donor CIK and CAPRI cells have special biological characteristics compared with other lymphocytes, they can overcome the obstacles of HLA molecules, reduce the alloreactivity, and thus significantly reduce the risk of GVHD.
In support of this premise, we find that these small molecules reduce the survival of mammalian tumor cells, impair bacterial growth, modulate cellular interactions between HSP70 and cochaperones, and alter interactions with substrates.
Furthermore, for both groups of animals, the experimental curves start from the same values so that we deduce that phenylpropanoid molecules reduce the latency time by lowering the lifetime τ.
Antibodies specific for either MHC class I or MHC class II molecules reduce the release of viable T lymphocytes from TNCs to the culture medium [ 78], thus suggesting that TNCs rescue immature T lymphocytes from apoptosis through the TCR-MHC interaction.
These purification steps are especially critical for high yields when attempting to join multiple DNA fragments in a defined sequence, because 'terminated' molecules will accumulate as a result of incomplete digestion in each ligation cycle, and these 'terminated' molecules reduce the yield of the desired molecule.
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Peter Seeberger of the Swiss Federal Institute of Technology, in Zurich, has automated the production of a limited number of these molecules, reducing the time required to make them from months to hours, and has produced a candidate vaccine for malaria.
Atomwise's software analyzes simulations of molecules, reducing the time researchers need to spend synthesizing and testing compounds.
The adsorption of protonated Schiff base molecules reduces the rate of hydrogen evolution reaction [74, 79, 84].
The presence of the solvent molecules reduces the thickness of the electric double layer, lowers the value of the mean electrostatic potential and raises capacitance.
The combinations of the small molecules reduced the total reactive oxygen species and malonaldehyde (MDA) levels and enhanced the production of glutathione peroxidise (GPx) enzyme under hypoxic conditions.
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