Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials.
A significant fraction of reactive regions is filled with a shell of water molecules, raising the issue about how phosphomevalonate kinase active site manages to prevent β,γ-bond hydrolysis during its catalytic cycle [35].
This lipoprotein is a component of triglyceride-rich VLDL cholesterol molecules, raising the possibility of an extra mechanism of β-cell damage.
* A newly discovered molecule raises the possibility of finding new ways to prevent H.I.V. infection.
The removal of one electron from the molecule raises the iron atom to the next-higher oxidation state (i.e., from +2 to +3), leading to the formation of salts containing the blue ferricinium cation, (C5H5 2Fe+.
Furthermore, they suggest that the functions of M2 related to latency maintenance are probably due to other motifs of this molecule, raising the possibility that separate regions of the M2 molecule regulate different branches of the pathogenicity program of MHV-68.
Despite much effort, significant titers of prion infectivity have never been produced by refolding pure PrP molecules, raising doubt about the validity of the "protein only" hypothesis.
The wavelength of the laser light can be tuned to interfere only with u-235 and "excite" the molecules, raising their energy level.
In this context, the fabrication of polymer-like materials structured on submicrometer or nanometer scale by self-assembly of existing or simple to synthesize molecules raises much hope, but poses significant scientific and industrial challenges.
Many biological signaling pathways transmit information through the amplitude or frequency of a shared signaling molecule and this has raised the long-standing question: can more information be transmitted through the amplitude or the frequency of a signaling molecule (Rapp et al., 1981; Li and Goldbeter, 1989)?
