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Nevertheless, this approach still cannot avoid partial removal of ECM molecules, particularly the weakly bound growth factors.
In terms of macrovascular disease the major contributing factors are inflammation, oxidation and the retention of atherogenic lipoproteins by extracellular matrix molecules particularly the proteoglycan, biglycan [ 35, 36].
Zhu et al. found that regions of the Aβ42 peptide have different propensities to bind small molecules, particularly the hydrophobic residues from Leu17-Ala21.
Actinomycetes, which are Gram-positive filamentous soil bacteria, are well known for their ability to decompose complex molecules, particularly the lignocellulose components, which make them important agents in decomposition processes [ 5].
The second mechanism by which HA may attenuate damage induced by oxidants involves the direct scavenging of oxidant molecules, particularly the reactive products of Fenton's reaction OH* radicals, by HA [ 101, 103, 116].
The risk of using these hard restraints is that the geometrical features of the molecules, particularly the target guest molecules – which are supposed to be based purely on experiment – are lost due to the incorporation of theoretical values, especially when these hard restraints are used in excess.
Similar(54)
Small molecules, particularly those that modulate key developmental pathways like the bone morphogenetic protein (BMP) signaling cascade, hold promise as tools to study in vitro lineage specification and to direct differentiation of stem cells toward particular cell types.
Several odor molecules, particularly those present in spices, are known ligands of not only GPCRs, but also the transient receptor potential (TRP) channel.
Some RNA molecules, particularly those in protozoan mitochondria, undergo extensive editing following their initial synthesis.
The cornified layer acts as an almost impermeable barrier, preventing diffusion of molecules, particularly those of a molecular weight beyond 500 Da [12], and with hydrophilic properties.
Some autoinducer molecules, particularly those with longer acyl chains, are relatively insoluble and care must be taken to ensure that all of the autoinducer has been removed.
Related(14)
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