Sentence examples for molecules on target from inspiring English sources

Because most tumors do not express major histocompatibility complex (MHC) class II, the potential antitumor-protective role of CD4+ T cells, which bind MHC class II molecules on target cells, has been less obvious.

Activating signals are interrupted when inhibitory receptors on NK cells engage MHC class I molecules on target cells [ 40].

The transduction efficacy with Ad vectors is however influenced by expression levels of the receptor molecules on target cells [ 5].

The killing function of NK cells is controlled by the activating and inhibitory receptors interacting with HLA molecules on target cells.

KIR molecules operate in both adaptive and innate immunity by modulating the development and activity of natural killer (NK) and T cell subsets through differential interaction with specific major histocompatibility complex (MHC) class I molecules on target cells.

Because the interaction between KIRs on NK cells with HLA molecules on target cells plays a key role in NK cell inhibition, it has been suggested that the KIR2DL3/HLA-C1 compound genotype results in a lower activation threshold of NK cells, thereby allowing faster NK cell activation compared with less favorable genotypes.

It has also recently been reported that elongation of a mouse MHC class I molecule on target cells abrogates its inhibitory effect on mouse NK cell killing [47].

HIV-1 entry to macrophages and CD4+ T cells is mediated through interaction of virion envelope glycoproteins with the CD4 molecule on target cells and also with chemokine coreceptors.

The classic drug-design strategy based on the "one-molecule-one-target" paradigm was found to be ineffective in the case of multifactorial diseases like AD.

While using small molecules to target on-pathway oligomeric species could lead to the inhibition of fibril formation, off-pathway oligomers are equally interesting as in some cases they have been shown to exhibit toxicity against numerous cell-lines [46,47].

Killer cell immunoglobulin-like receptors (KIR) play a critical role in the regulation of natural killer (NK) cell activity through their recognition of class I MHC molecules expressed on target cells.