Sentence examples for molecules on immune from inspiring English sources
In order to define the absolute number of IL-7 receptor molecules on immune cell subsets on a single cell level, we obtained a preparation of the anti-IL-7 receptor alpha chain monoclonal mAb (clone R34.34) labeled with a single APC molecule.
PD-1 and CTLA-4 are negative co-stimulatory molecules on immune cells.
One potential mechanism underlying the chronic disease is believed to be viral escape from immune surveillance via upregulation of inhibitory molecules on immune cells by HCV.
However, the direct effect of those molecules on immune cells has not been investigated, so candidate proteins can possibly act as danger signals to stimulate the immune response for eradication of tumor cells after irradiation [ 16].
Bispecific antibodies (BsAbs) can effectively link target cells to cytotoxic trigger molecules on immune effector cells, and may overcome some of the limitations of conventional mAb (Segal et al, 1999).
In contrast to positive co-stimulatory molecules (such as the CD80/86 ↔ CD28 pathway), cross-linking of negative molecules on immune cells, especially T cells, by their respective ligands suppresses immune cell activation or even induces apoptosis resulting in lymphopenia.
A promising drug target, say several scientists, is the portion of the receptor molecule on immune system cells that is shared by both IL-4 and IL-13.
Support for this comes from other group B SRCR molecules found on immune system cells including CD5 which is a positive and negative regulator of TCR and B cell receptor signaling [ 15] and CD6 which functions as an adhesion molecule [ 16] and for activation [ 17- 19].
Extensive study of the infection mechanism has revealed that HIV enters the immune cells by HIV envelope glycoprotein conjugation, which recognizes the receptor molecules on the immune cells [ 3].
This phenomenon suggested that a balance exists between the negative and positive co-stimulatory molecules on activated immune cells.
Extravasation of circulating immune cells is a multi-step process that is regulated by the sequential interaction of different adhesion and signaling molecules on the immune cells and on the endothelium.
