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Therefore, it is feasible that aggregation of the floating cells was initiated by the direct binding of LL-37 to the cell surfaces and allowed for interaction between LL-37 molecules on adjacent cells (Fig. 4B).
In contrast, CD47/IAP-SIRPα interactions are typically trans in nature, interactions being between molecules on adjacent cells.
E-cadherin is a glycoprotein with an extracellular domain that interacts with E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells.
It is mediated by specific cell surface lectins, able to bind directly to mannose residues of mannan molecules on adjacent cells.
The EpEx further contains EGF and thyroglobulin repeat-like domains, which are involved in both reciprocal interactions between EpCAM molecules on adjacent cells and lateral interactions between EpCAM molecules (4), and comprises 12 highly conserved cysteine residues forming disulfide bonds on the EpEx.
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For the SCR process, nitrous oxide is also formed by nitric oxide molecules adsorbed on adjacent centres of the polymeric vanadia.
These sites are also assumed to be energetically equivalent and distant from each other so that there are no interactions between molecules adsorbed on adjacent sites.
In the cis- NO 2 dimericis- NO 2 two adimeric NO moleculespecieso adjacentwoo2+ sites interadsorbed each other due to the opposed orieNOation of the unoccupied d orbitals of the two Co2+, resulting in easy formolecules a N–N bond twoough the 2π*–2π* hybridizadjacent
JAMs are expressed at the intracellular junctions of BECs and CPEs and have different patterns of homophilic and heterophilic interactions with JAM molecules on the adjacent cell, forming dimers that are part of the tight junction structure [ 35].
To initiate the adhesion process, extracellular domains of cadherins engage in the Ca 2+-dependent homophilic trans-interaction with identical cadherin molecules on an adjacent cell, while their cytoplasmic tails bind to p120- and β- (or its homolog γ-) catenin proteins.
TSLP is released in response to activation of Toll-like receptors in the epithelium and directs T-cell differentiation towards a Th-2 phenotype by up-regulating the co-stimulatory molecule OX40 (CD134) on adjacent DCs [ 68].
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