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To comprehend how the key molecules of innate immunity respond to this double infection, the levels of HSP-70, crustin, penaeidin-3a, and C-type lectin-br1 were assessed by quantitative PCR.
These key effector molecules of innate immunity typically possess antimicrobial activity against bacteria, viruses, fungi and/or parasites [1], [2].
Initially, AMPs were characterized as effector molecules of innate immunity as they provide a first barrier of defence against microbial pathogens [4].
Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians.
This observation strongly supports the previous observation that NOS is a dynamic multifunctional enzyme that not only required for physiological integrity, but also participate as an important effectors molecules of innate immunity.
As many different coronavirus proteins have been discovered to target various molecules of innate immune system [29], DUB activity of PLP2 may be one of the most effective arsenal for coronavirus to retard and/or escape from the type I IFN response.
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It may function as an effector molecule of innate immune system [58], [60].
Our findings show Aβ possesses antimicrobial activity and may function in vivo as an AMP and, thus, play a role as an effector molecule of innate immunity.
IFN- γ is an important molecule of innate and adaptive immune responses in vertebrates [ 20– 23].
The cytokine migration inhibitory factor (MIF) has recently emerged as an important effector molecule of innate immune responses and sepsis.
CRP is a pattern-recognition molecule of innate immunity as an acute-phase reactant and a hallmark of low-grade systemic inflammation.
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