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As increased nonmatrix degrading capabilities of MMP are recognized, however, i.e., cytokine activation, processing of proteins to molecules of distinct biologic function, it becomes less clear whether the nonselective inhibition of MMP activity for all pathologic processes involving MMP is appropriate.
Conditional ligands integrate the use of MHC-based multimer arrays with high-throughput flow cytometric analysis of antigen-specific T cells, as they allow the rapid synthesis of MHC molecules of distinct specificity through a peptide-exchange protocol.
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Indeed, recent studies of non-Hodgkin lymphomas demonstrated that the quantitative expression of CD20 molecules on distinct histological types of lymphoma correlates with rituximab efficacy [39], [40].
It is tempting to speculate that the simultaneous binding of two GR molecules to distinct but proximal HREs helps displace nucleosomes that block access to the DNA.
Library complexity curves, which plot the number of distinct molecules against the number of molecules sequenced, were used to characterize the rate of diminishing returns because a library of finite complexity is sequenced more deeply.
Since a mesoscopic MFD simulation may comprise thousands to millions of molecules, distinct functions for the initial mapping of their fragments to their spatial box coordinates are necessary to obtain the start configuration of the simulation.
We used automated screening assays to evaluate thousands of chemical compounds and found that diverse classes of neuroactive molecules caused distinct patterns of behavior.
That's where the magic of the DNA barcode comes in: colored-dots can be arranged into geometric patterns or fluorescent linear barcodes, and the combinations are almost limitless — substantially increasing the number of distinct molecules or cells scientists can observe in a sample, and the colors are easy to distinguish.
Our data demonstrates IUE mediated cortical gene silencing as an excellent approach to study the role of distinct molecules for epilepsy associated focal brain lesions and suggests LRP12 and lipoprotein homeostasis as potential molecular target structures for the emergence of epilepsy-associated FCDs.
The limited number of patients in our study precluded assessing the individual effects of distinct molecules within the fluoroquinolone class.
Activation of innate immunity is mediated through recognition of distinct molecules that are present on a broad diversity of microorganisms.
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