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While the C-terminal residues are identical in those and in CP04, the remaining parts of the molecules may influence the binding mode of the common sequences.
We hypothesized that such molecules may influence host cell metabolism in such a way that effective viral replication would be altered.
To investigate this mechanism further we aimed to: identify a cell line model to allow repeatable and robust experiments; determine whether or not epithelial adhesion molecules were affected by stromal culture; and determine which stromal signalling molecules may influence cell adhesion in 3D epithelial cell cultures.
This finding suggests that the pre-treatment activity state of antagonistic VDR-dependent molecules may influence cell-specific 1α,25- OH 2 D3 growth responses.
Our analyses in E/P-selectin mutant mice suggested that these adhesion molecules may influence the development of CIA by altering the production of MIP-1α and IL-1β.
The HER2/neu antibody trastuzumab induces tumour regression in approximately 30 – 35% of patients with HER2-amplified metastatic breast cancer (Hsieh and Moasser, 2007), indicating that additional signalling molecules may influence the biological response to trastuzumab.
Similar(51)
Ligands binding to distinct epitopes on the same target molecule may influence each other, for example, inhibiting binding to adjacent epitopes.
Among proposed invasion-related genes with reported altered expression in tumor cells are cell adhesion molecules, proteases and cytoskeletal molecules that may influence motility [ 5].
The predominance of epimerization over isomerization products with substoichiometric borate suggests that one borate can influence the reactivity of several sugar molecules and may influence the Sn active site directly.
In addition, cells contain a diverse and complex signaling network with many molecules that may influence cAMP microdomains.
These results indicated that although structurally cytokines share the same signal transducing unit, its activation may elicit different effects, like different global phosphorylation level, activation of different STAT molecules what may influence the final biological activity.
Related(20)
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