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Molecules lacking one of these interactions showed other modes of action resulting in weaker binding or dramatically reduced internalization rates [31].
Molecules lacking one of these interactions have shown reduced binding and internalization rates [ 27].
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Using computational design, we engineered an SspB heterodimer whose subunits did not form homodimers. Experiments with the designed molecule and variants lacking one or two tails demonstrate that both XB modules are required for strong binding and efficient substrate delivery to ClpXP.
Fluorophore-assisted carbohydrate electrophoresis (FACE) and size exclusion chromatography (SEC) are used to analyze the CLDs of amylopectin and amylose molecules in wild-type and transgenic rices, the transgenic lines lacking one or more SBEs.
Lastly, recently discovered alternatively spliced mRNA molecules encode soluble CTLA4 molecules lacking transmembrane domains.
Organometallic coordination compounds are sometimes characterized by "sandwich" structures, in which two molecules of an unsaturated cyclic hydrocarbon, which lacks one or more hydrogen atoms, bond on either side of a metal atom.
Although deoxyartemisinin (DOArt) was also present in powdered leaves, DOArt lacks one oxygen molecule in the peroxide bridge found in artemisinin and is reported to have no biological activity [ 31].
Notably, several groups of Thx-like proteins lack one or both cysteines from the archetypic CxxC motif common to most thioredoxin-like molecules.
This sequence is the smallest putative macronuclear chromosome ever identified (although, one should keep in mind that these molecules lack centromeres, unlike true chromosomes).
Small molecules lack sufficient steric bulk to prevent interactions between large peptide surfaces.
Because the recombinant molecule lacks glycosylation and has an extra amino-terminal methionine, the native molecule may have greater biologic potency than the recombinant one.
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