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The rate of stretching of individual molecules is highly variable and depends on the molecular conformation that develops during stretching.
For drug targeting of proteases, selectivity for individual molecules is highly desired and can be met by high yield active site specificity profiling.
Cumulative evidence suggests that the three helical scaffold domain used as basis for these molecules is highly suited to create a molecular affinity handle for vastly different applications.
Controlling the enzymatic activity of specific individual MMPs by antagonist molecules is highly desirable, first, for studying their individual roles, and second as potential therapeutic agents.
Monitoring enzymatic activity in vivo of individual homologous enzymes such as the matrix metalloproteinases (MMPs) by antagonist molecules is highly desired for defining physiological and pathophysiological pathways.
Indeed, the ranking of the small molecules is highly dependent on the program, as observed in Fig. 1 and Additional file 1: Figure S2, for Cn and Hbp, respectively, where a divergence of the results is observed.
Similar(44)
But these molecules are highly reactive and capricious, sometimes attacking other cells and damaging tissue.
Nitric oxide donor molecules were highly active within 6 hours of application.
Susceptibility tests showed that most of the synthesized molecules were highly active against multiple bacterial strains.
In addition to this protein binding and CT-DNA intercalation studies showed molecules are highly potential.
Recently, functional nucleic acid molecules are highly regarded for the determination of heavy metal ions.
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