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Screening of such a large number of molecules is complicated with both experimental and computational techniques.
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Studies of functions of these clustered cell adhesion molecules are complicated by their molecular diversity with cis-homodimers and cis-heterodimers on the same cell surface and by cross-regulations of the encoding genes 29, 30.
The arduous task of rationally designing small-molecule enzyme inhibitors is complicated by the inherent flexibility of the protein scaffold.
However, despite the inherent advantages of 18F like the favorable physical half-life of 109.8 min and the convenient availability as cyclotron-produced [18F]fluoride at high specific activity, the production of 18F-labeled small-molecule PSMA inhibitors is complicated and often low yielding [13 20].
"This has led to the development of a whole new therapeutic strategy that, instead of correcting proteins one at a time, recognizes that the environment of the protein is what has changed" The challenge is the need to come up with a molecule for every allele, because folding is complicated.
Characterization is complicated by the observation that many of these molecules appear to perform overlapping roles.
Sometimes that is complicated.
The issue is complicated.
Sometimes history is complicated.
The setup is complicated.
The process is complicated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com