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We investigated if IFNB1-mediated autophagosome formation was dependent on ATG7, which is considered one of the core autophagy molecules indispensable for canonical autophagy.
This forceful adhesion seals the paracellular route and prevents entry of a variety of substances, both small and large, into brain from blood, while simultaneously creating a foundation that allows BMEC transporters to take up or expel molecules indispensable for, or harmful to, the physiological functions of the brain.
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On the mechanistic level, Sck was identified as a novel molecule indispensable for CD95's induction of cell cycle progression.
Furthermore, it was reported that MHCI molecules are indispensable for developmental refinement in the LGN, i.e. for removal of excess synapses during normal development [ 12, 23].
The physical interaction of mammalian prominin-1 with protocadherin-21, a photoreceptor-specific adhesion molecule, appears indispensable for the organization of the rod outer segment [9].
This may explain why ATP hydrolysis is dispensable for the recombination reactions catalyzed by Rad51 in vitro (assessed mostly by joint molecule formation) but indispensable for recombination in vivo [25].
15– 17 Because PD-1-deficient mice suffer from spontaneous autoimmune diseases, PD-1 is considered to function as an immune checkpoint molecule that is indispensable for immunological homeostasis.
TPE spectra of fluorescent molecules provide indispensable information for the use of these techniques.
This may derive from the fact that 5-minute measurements can capture activation trends of important molecules such as ERK that are indispensable for cell migration but are usually attenuated at 1 to 2 hours after EGF stimulus when motility has started becoming a stable biophysical response.
With either nanobiotechnology or bionanotechnology, biological molecules are indispensable building blocks for fabricating functional nanomaterials, nanodevices and nanosystems.
doi: 10.1038/sj.bjc.6600574 www.bjcancer.com © 2002 Cancer Research UK Adhesion molecules expressed on metastatic or disseminated cells are indispensable for the cell's transmigration through the endothelium, locomotion in the blood-lymph circulation, and localization in the target organ (Lester and Maccarthy, 1992).
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