These molecules include potential markers of endothelial and myocardial injury (talin, filamin, desmoglein, obscurin and titin), leukocyte activation (AMICA1, CAECAM, CXCL12, GDF15 and LAIR1), pathogen immune recognition (DMBT1, ABCB9) and cytokine regulation (CSMD3, meprin A).
Although systematic use of these molecules cannot be advocated, several areas of uncertainty remain, including potential benefits in patients with more severe illness or in specific subgroups.
Selective conversion of cellulose to small organic molecules, including carboxylic acids, represents a potential route for upgrading biomass resources to value-added chemical precursors.
The growth of a choroidal neovascularisation (CNV) is probably mainly driven by VEGF, but clinical studies and laboratory data have suggested that other potential signal molecules, including chemokines, could be involved in CNV growth [ 4- 7].
The chemokine receptor CCR5 is required for cellular entry by many strains of HIV, and provides a potential target for molecules, including antibodies, designed to block HIV transmission.
For a number of essential genes we find potential binding small molecules, including approved drugs such as Ribavirin, which may inhibit the respective gene products.
Rodent studies have identified a number of potential regulatory signalling molecules, including the myogenic regulatory factors (MRFs; Hughes et al., 1993) and the signalling enzymes, calcineurin (CaN) and calmodulin kinase II (CaMKII; Chin, 2005; Bassel-Duby and Olson, 2006).
A myriad of signaling molecules including some bacterial protein kinases have been studied as potential drug targets.
For example, several ER membrane-anchored signaling molecules including Ire1 and PERK are now being evaluated as potential anti-cancer targets [8].
Membrane vesicles released by neoplastic cells into extracellular medium contain potential of carrying arrays of oncogenic molecules including proteins and microRNAs (miRNA).
