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Particular advantages of proteins as drugs relative to small organic molecules include high affinity and specificity afforded by a larger molecular recognition surface and much lower probability of off-target toxicities due to metabolic byproducts.
The advantages of solution processable molecules include high purity, well-defined molecular weight, and easier fabrication steps compared to vacuum deposited methods.
Clearly, LPS* molecules include high affinity binding sites for vancomycin.
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Loss of TRMT10A protein induced apoptosis in rat β-cells and increased stress-induced apoptosis by many endogenous molecules including high levels of glucose.
Also, other molecules, including high-mobility group box 1 (HMGB-1), have a pivotal role in the innate immune response to diseases, including sepsis [ 11].
These include: High blood pressure.
Single-molecule technologies, including high-throughput methods for single-molecule DNA sequencing, are being commercialized, and early outreach efforts are bringing single-molecule magnetic bead experiments to high school classrooms.
These include: –High-Tech.
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The hyaldherin molecules include structural matrix hyaluronic acid-binding proteins as well as cell surface receptors that bind with high affinity to hyaluronic acid [ 74].
Endothelial cells are covered by a layer of membrane bound molecules including proteoglycans containing high concentrations of heparan sulphate such as syndecans and glypicans and loosely bound plasma proteins, collectively called the glycocalyx [3, 4].
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