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The concept of utilizing small molecules, in place of proteins, that exhibit biological activity towards a given protein target, whether activating or inhibiting, is known as non-peptide mimetics.
These studies have enabled important structural information on the position of gas molecules contained within these porous materials to be determined and the nature of the interactions involved in holding these molecules in place to be investigated.
Methods are currently being developed to accelerate the entire differentiation process, including neuronal maturation, using small molecules in place of recombinant proteins to more efficiently manipulate cell signalling systems [ 37].
Interestingly, we found that 21 of such these GNGs code for tRNA charging reactions that can be converted to NGNG consistencies by including the charged and uncharged tRNA molecules in place of the corresponding amino acids in the biomass equation.
Under typical polyol reaction conditions (>180 °C), we observed that inclusion of sugar molecules in place of the PVP surfactant to attempt to increase the aqueous stability of the product BiNPs resulted in a highly polymerized solvent/surfactant/particle aggregate, which was difficult to work up further.
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However, β-O-methylgalactose and Gal do not bind as tightly as LacNAc or lactose, as their Kia and KA values indicate, suggesting that the second monosaccharide is critical for holding the acceptor molecule in place.
The serotonin receptor keeps the LSD molecule in place by folding over it, and sometimes, this pair of molecules hides away inside nerve cells.
Three basic residues, K294(n), K457(n+1) and R459(n+1) stabilize the negative charges on the phosphates and lock the ATP molecule in place.
If the proton is delivered from a water molecule, we would expect that a mutant such as F28H or H64Q could help to keep that water molecule in place, but each of those is not faster than F28L or H64A, respectively.
These materials, also know generically as "rate-dependent materials," work by having their molecules freeze in place when struck hard, but are pliant when moved gently — just like water, which is a rate-dependent material of a sort.
Further, the cells and their structural molecules remain in place, in order of the sequence in which they were formed, throughout life.
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models in place
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pathways in place
atoms in place
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