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3DAPfp and 3DXfp are suitable for stereoselective searches for shape and pharmacophore analogs of query molecules in large databases.
High temperature X-ray diffraction measurements of C70 peapods below the coalescence temperature show that confined C70 molecules in large tubes undergo an orientational transition to free rotations.
Our findings reveal that the PEG molecules attached to the cores immobilize water molecules in large regions of ~85 nm, which would lead to blood half-life of a few tens of minutes.
How fishes are able to detect trace molecules in large bodies of water is not understood.
Moreover, the method has great potential for super resolution imaging and 3D tracking of single molecules in large, living specimens such as embryos at a millisecond time scale.
The poorly defined factors present in bovine serum, as well as in conditions when feeder cells are used, and the high variability of the embryoid body system prompted us to develop a new, defined, animal product-free differentiation system to generate clinical grade hematopoietic progenitors easily applicable to test the effect of small molecules in large scale screens.
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In the early years, the main achievement of biotechnology was the ability to produce naturally occurring therapeutic molecules in larger quantities than could be derived from conventional sources such as plasma, animal organs, and human cadavers.
Crystal growth, and the related diagenetic increase in bone crystallinity observed post-mortem, could contribute to the entrapment and protection of endogenous DNA molecules in larger crystals, as observed with the TP1RE and TP2RE extracts.
-Hyperforin is no doubt an attractive compound for chemical, biotechnological, and pharmaceutical research with a view not only to produce this molecule in large scale with better safety measures but also to design and explore broader chemical and biotechnological space in obtaining novel hyperforin analogs with improved biological and pharmacological profiles.
The large numbers of molecules in a large volume makes tracking individual molecules or exact stochastic simulation (e.g. [32], [51], [52]) computationally expensive, and possibly prohibitive, as demonstrated by the comparison between Smoldyn and NeuroRD (Table 4).
TMP molecules aggregate in large and compact islands on both metals and their assembly follows a normal coarsening.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com