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In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein protein interactions, including those involved in cancer and HIV.
Once the RNA molecules have successfully entered the target cells, they could inhibit the expression of specific gene sequence through RNA interference (RNAi) mechanism and generate therapeutic effects.
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For small molecules, PBPK models have successfully been used to predict human exposure and to design phase I studies.
Three tri-benzimidazolyl star-shape molecules have been successfully designed and applied as new fluorescent chemosensors for the detection of fluoride ion for the first time.
Amino acid extensions either at the N- or C-terminus of these ZHER2 affibody molecules, have been successfully employed for site-specific radiolabeling of the tracer candidates.
Thanks to the recent advances in polymer chemistry, the POSS molecules have been successfully incorporated into well-defined organic polymeric structures leading to the creation of a plethora of well-defined hybrid nano architectures with novel properties and applications.
A variety of molecules have been successfully accelerated.
MPc molecules have been successfully anchored on the surface of rGO sheets by noncovalent π π stackable interaction.
Many complex molecules have been successfully synthesised for the first time, and for others dramatic improvements in route have been achieved.
Currently, some miniaturized chemical gas sensors based on nanoscale metal oxide semiconductor, which rely principally on monitoring the direct change in the conductance in adsorption and desorption of gas molecules, have been successfully obtained [13 15].
Cell adhesion molecules have been successfully used in the treatment of chronic inflammatory diseases.
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