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Several other molecules have demonstrated their activity in the same context and combination strategies are being explored.
The types of drugs mentioned above as well as several other molecules have demonstrated potential as PET ligands for non-invasive in vivo imaging of the VEGF/VEGFRs.
Several p53-targeting small molecules have demonstrated very promising activity in pre-clinical studies but have yet progressed to the clinical setting.
In the past 20 years, a steadily increasing number of electron electron coincidence experiments on atoms and molecules have demonstrated the capability of investigating complicated systems with sensitivity and specificity well beyond the limits imposed by conventional electron spectroscopies.
In endocrine tumors, several molecules have demonstrated efficacy in terms of progression free survival during phase III trials such as vandetanib and cabozantinib in medullary thyroid carcinoma, sorafenib in differentiated thyroid carcinoma and everolimus or sunitinib for pancreatic neuroendocrine tumors.
All these molecules have demonstrated axon growth promoting properties for different neuron types either in culture or in vivo, in most cases including sensory neurons like those innervating the antler.
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Recent success in reconstituting heterologous pathways in microorganisms for high-level production of small molecules has demonstrated the feasibility of achieving titers in the g/L range.
52, 53 Clinical trials using high doses of the antioxidant idebenone, a coenzyme Q10-related molecule, have demonstrated that this compound is able to improve both cardiac hypertrophy and neurological symptoms associated with the disease.
Each candidate small molecule has demonstrated favourable pharmacokinetic/pharmacodynamic characteristics and efficacy in several murine autoimmune disease models (Chaudhary et al, 2012).
Preclinically, the small molecule has demonstrated FGFR-dependent anti-tumour effects in a breast cancer model independent of its activity against VEGFR and PDGFR β (Dey et al, 2010).
The apparent functional redundancy within the vitronectin molecule has demonstrated that small peptides can be sufficient to mimic the hPSC-supporting effects of ECMPs and suggests that the maintenance of pluripotency may not depend entirely on specific CAM-ligand interactions.
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sequences have demonstrated
genes have demonstrated
chemistries have demonstrated
compounds have demonstrated
medications have demonstrated
pathways have demonstrated
particles have demonstrated
molecules are demonstrated
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molecules have worked
molecules have emerged
molecules have become
molecules have been
molecules have shown
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