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Especially, the enhancement of tumor retention results in higher contrast and opens the possibility of using small molecules for therapy.
The emergence of structure-based drug design for the development of small synthetic molecules for therapy holds promise, in spite of formidable technical challenges.
Recently, with the progress of pathogenic mechanism of ALS, several potential target molecules for therapy have been demonstrated.
For example, a new high-throughput sequencing strategy was recently described [ 54], allowing measurement of gene expression profiles of hundreds of genes in thousands of samples to identify small molecules for therapy of hormone-refractory prostate cancer.
Therefore, we aimed to investigate the mechanisms of breast cancer cells that generate gaps – and as we now call them – 'circular chemorepellent-induced defects' (CCID) into LEC monolayers to identify potential target molecules for therapy.
This review provides an update on the understanding of frataxin function, developments of animal and cellular models of the disease, and recent advances in trying to uncover potential molecules for therapy.
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These observations support the hypothesis that HMGB1 plays an important functional role in the pathogenesis of arthritis and may represent a novel target molecule for therapy.
The rapid blood clearance and good tumour penetration of scFvs offer potential advantages over larger antibody molecules for cancer therapy such as radioimmunoguided surgery and antibody-directed enzyme-prodrug therapy (Wels et al, 1992; Mayer et al, 2000).
High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy.
Consequently, these compounds emerged as promising molecules for the therapy of Alzheimer's disease.
Finally, the products of genes causing disease become target molecules for gene therapy.
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com