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Another approach has been to use complementary molecules for proper identification.
However, how Ca2+ coordinates structural components and signaling molecules for proper cell motility had remained elusive.
The non-classical class II DM molecule, HLA-DM in the case of humans, possesses critical function in assisting the classical MHC class II molecules for proper peptide loading and is highly conserved in tetrapod species.
Some of the functions of tsRNAs/tRFs have been connected to stress, metabolism, and differentiation suggesting the species may be critical regulatory molecules for proper cellular growth and maintenance [ 3, 7– 12, 15, 19, 19, 20].
It has been shown that integrins are critical molecules for proper development of NC cells (NCCs), and perturbation of integrin molecules may lead to immobility and apoptosis of NCCs.
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sGAG is a key molecule for proper cartilage functioning, and the amount of sGAG content is an indicator of cartilage health [ 40].
In rats, MDGA positive cells were found in the pontine migratory stream, suggesting that these circumferentially migrating neurons may rely on this cell adhesion molecule for proper neuronal migration (Litwack et al., 2004).
This might be due to their methodology of immunostaining for HLA class I as they stained only using HC10 antibody which stains only HLA class I heavy chains (HLA-HC) but they did not stain for β2m which is an essential molecule for proper function of HLA class I. Overall survival was significantly worse in patients with low expression of HLA class I.
First described in Caenorhabditis elegans as small temporal RNA molecules required for proper development, miRNAs are now recognized as a new class of trans-factors that regulate gene expression, which until now have been the exclusive domain of proteins [28], [33].
However the link between developmental signals regulating adhesion molecule dynamics for proper epithelial organization remains poorly understood.
We also examined Fasciclin II, a cell adhesion molecule necessary for proper synaptic structure and stabilization at the NMJ [44], [45].
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