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We further demonstrate that the method can be applied to perform a clustering analysis of MHC specificities and suggest using this clustering to select particularly informative novel MHC molecules for future biochemical and functional analysis.
It stresses the importance of the availability of large and representative HLA binding data, and it suggests that the development of the next generations of improved pan-specific predictors can be optimized through targeted selection of peptides and HLA molecules for future data inclusion.
Collectively, the results presented here highlight possible signaling pathways and molecules for future research.
Thus, ET-1 and NO should become important target molecules for future therapies aimed at stopping cartilage destruction.
ET-1 and NO should thus become important target molecules for future therapies aimed at stopping cartilage destruction.
Endothelin-1, TGF-β, serum galectin-3 and HIF appear to play important roles in these pathways and may be promising target molecules for future intervention studies.
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Finally, schiff base 13 emerged as the lead molecule for future design and development of Hsp90 inhibitors as anticancer agents.
Thus, the present study shows that 3,3′,4′-Trihydroxyflavone isolated from J. wynaadensis is an interesting biopharmaceutical agent and could be considered as a source of antimicrobial agent for the treatment of various infections and used as a template molecule for future drug development.
Efforts are underway to purify the neurotoxic molecule for future investigations.
The high expression in some tumors suggests that it may represent a potential target molecule for future diagnostic and therapeutic applications.
Eight such ZHER2 affibody molecules, designed for future radioimaging investigations, having different C-terminal peptide extensions aimed for radioisotope (99mTc -chelation, were successfully produced and recovered in a single step to high purity using the anti-idiotypic affibody ligand for the affinity purification.
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