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Figure 5: G28A Jc1 requires fewer miR-122 molecules for efficient infection than WT.
Successful application of RNAi in vivo depends on intracellular targeted delivery of siRNA/shRNA molecules for efficient knockdown of the desired gene.
The present work has significant implications on the design of robust porous organic solids from small molecules for efficient capture of CO2 and H2 gases.
These results suggested that replication of the G28A mutant virus was still miR-122 dependent, and led us to hypothesize that this virus replicated in cells expressing the miR-122 decoy because it requires fewer bioavailable miR-122 molecules for efficient replication than WT Jc1 HCV.
However, the successful application of these molecules for efficient delivery in vivo requires the design of noncytotoxic, nonimmunogenic, serum compatible and biochemically labile carriers, systematic analysis of their mechanisms of action, and extensive animal studies.
However, ZnO photoanodes based on nanorod arrays suffer from limited surface area that can absorb dye molecules for efficient light harvesting when compared to the electrodes based on nanoparticles.
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An additional common thread between class Ia and class Ib molecules is their critical interaction with the β2-microglobulin (β2-m) molecule for efficient cell surface expression (Hofstetter et al., 2011; Ulbrecht et al., 1999).
Silencing of b2m should result in downregulation of surface expression of class Ia as well as class Ib molecules, since they require association with the β2-m molecule for efficient cell surface expression.
We conclude that effective immunotherapy is likely to require upregulation of E-cadherin expression by pancreatic cancer cells or the development of cytotoxic immune cells that are less dependent on this adhesion molecule for efficient effecter function.
Forced by the EEF, WO3 nanoplates anchored silane molecules (WO3-SiH2NH2) for efficient photoelectrochemical (PEC) water oxidation shows 44.8% photocurrent enhancement.
Classically, PRs are defined as ligand-activated transcription factors that bind target gene promoters or enhancers as dimers capable of recruiting coregulatory molecules required for efficient transcription.
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