Sentence examples for molecules for degradation from inspiring English sources

In addition to blocking mRNA translation, sRNA:mRNA duplex formation can target both RNA molecules for degradation by double-stranded RNA cleaving ribonucleases (e.g. RNase III) [8].

c-Cbl targets many signaling molecules for degradation, including ZAP70 [ 18].

Therefore, MARCH1 and MARCH8 induce lysosomal degradation of HLA-DO, whereas MARCH9, although having the greatest influence on internalisation of DO does not target molecules for degradation.

The Smad1 linker region comprises several sequential phosphorylation sites for cyclin dependent kinases (CDKs), MAPK and glycogen synthase kinase three beta (GSK3β) that regulate their transcriptional capacity and prime Smad molecules for degradation via the ubiquitin proteasome pathway [ 9, 45].

Ubiquitin and SUMO, two tags thought to target molecules for degradation, exist in the toxic protein aggregates that characterize neurodegenerative diseases, suggesting that while the cell does not have trouble recognizing harmful proteins, the proteasome may have trouble breaking them down.

A second region of A20 catalyses Lys48-linked ubiquitination that targets the molecule for degradation by the proteasome [ 41].

They operate via their complementarity to a stretch of mRNA sequence, and affect the level of gene expression by targeting the mRNA molecule for degradation.

Therefore, many families rich in pseudogenes participate in the synthesis of defense compounds or in the recognition of molecules destined for degradation.

Endosomal compartments are best known for incorporating membrane molecules derived from the cell surface, and sorting these molecules for either degradation or recycling back to the cell surface.

Coupling the phosphorylation to downstream internalization may also be important for damping down tetherin signaling by targeting activated molecules for endosomal degradation.

MARCH9 was by far the most efficient at inducing intracellular redistribution of DO but did not target molecules for lysosomal degradation.