Sentence examples for molecules critical for from inspiring English sources

c-JUN, MDM2 and FoxM1B were previously suggested as signal molecules critical for HCC development [10], [19], [20].

As NELL1 binds to, and is phosphorylated by, PKC-β1 via the EGF domains [52], it has been suggested that this protein belongs to a novel class of cell-signalling ligand molecules critical for growth and development.

This could be either through indirect mechanisms, including regulation of factors important for tissue patterning, intracellular signaling or cell specification, or through direct regulation of axon guidance molecules critical for sensing the environment during axon extension.

Since BCR (BCR-ABL1) and Akt are cell signaling molecules critical for the proliferation of CML cells [22], our finding provides a molecular basis for the involvement of AQP5 in the progression of CML.

Genes encoding molecules critical for the extracellular matrix (ECM) architecture (COL6A1, COL6A2 and COL6A3) and ECM re-modeling enzymes (TIMP1 and TIMP2) were differentially expressed in AE skin (Figure 6A and Supplementary Table S1).

Taken together, these data demonstrate that while DHA does not directly affect the surface expression levels of the IFNγ receptor, it does impair cell activation by disrupting the localization of the receptor to lipid rafts and thus, phosphorylation of key signaling molecules critical for cell function.

However, over expression of Fto resulted in a 4-fold increase in the mRNA levels of Stat3, a signalling molecule critical for leptin receptor signalling, suggesting a possible candidate for the mediation of Fto's actions.

In juvenile and adult male zebra finches, endogenous levels of FoxP2, a molecule critical for language, decrease two hours after morning song onset within area X, part of the basal ganglia-forebrain pathway dedicated to song.

The role of PD-1, a co-inhibitory molecule critical for immune homeostasis and tolerance, was tested in a model of CNS-myelinopathy associated with secondary, low grade inflammation of high pathological relevance.

For example, in OLpres, we found target genes encoding Cntn1/F3, an immunoglobulin superfamily cell adhesion molecule critical for promoting OL maturation [33], [34], [35]; Tcf4, a high mobility group (HMG) family downstream effector of Wnt signaling and transcriptional inhibitor of OL maturation and myelination genes [36], [37], [38], [39]; and Mobp, an essential myelin protein [40].

Using this same behavioral assay, we previously found that a mutation in one of the key clock genes (Period2) as well as the loss of vasoactive intestinal peptide, a signaling molecule critical for coupling within the central clock, reduced recall, but not acquisition, of conditioned fear [8], [26].