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The developed method, named NetHiKe (Network-based Hidden Key molecule miner), was able to detect potential key molecules by utilizing the human biomolecular network as a knowledge base.
It has been demonstrated that the tropism of MV can be retargeted to many different cell surface molecules by utilizing a fusion protein consisting of single-chain antibodies (scFv), peptides, growth factors or cytokines fused to the extracellular C terminus of the H protein [ 23].
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Design of these molecules was performed by utilizing a co-crystal structure for structure-based drug design.
The first anion-templated synthesis of a lanthanide-containing interlocked molecule is demonstrated by utilizing a nitrite anion to template initial pseudorotaxane formation.
The invasion score was determined on H & E stained sections, and sections with strong cartilage invasion were also stained for the aforementioned molecules by immunohistochemistry utilizing the avidin biotin detection system.
This is the most reliable way to design new potent active molecules having similar scaffolds by utilizing their biological data in computational predictions.
Electrically controlled release of DEX molecules can be achieved by utilizing the unique redox properties of the GO/PPy-DEX nanocomposite film.
The NF can encapsulate small-molecule drugs within its hydrophobic inner core and strongly secure various RNA molecules (siRNAs, miRNAs, and oligonucleotides) by utilizing Zn II -DPA and a robust CaP coating.
We explored the possibility of controlling charge distribution in the homogalacturonan regions of pectin to produce a population of demethylesterified molecules with desirable functional properties by utilizing consecutive treatments with pectin methylesterases (PME) having different modes of action.
Subsequently, we inhibited the class I PI3K pathway at different levels by utilizing small molecules inhibitors ZSTK474, KP372-1 oRapamycinin to specifically target pan-class I PI3K, Akt and mTOR respectively.
In this study, we examined the importance of the class I PI3K/Akt pathway in promoting tumourigenicity of canine cell lines by utilizing small molecules ZSTK474, KP372-1 and Rapamycin that selectively inhibit class I PI3K, Akt and mTOR, respectively.
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CEO of Professional Science Editing for Scientists @ prosciediting.com