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The five known subtypes of DA receptors belong to two main classes: D1-like receptors (with the subtypes D1 and D5) activate adenylyl cyclases through interactions via Gs, whereas D2-like receptors (comprising D2, D3 and D4 subtypes) inhibit adenylyl cyclases and other effector molecules by interacting with Gi/Go [for reviews see 80] [83].
It may function as intracellular and extracellular signalling molecules by interacting with specific proteins involved in the regulation of proliferative and apoptotic cellular processes [ 14- 16].
10 12 For example, the functional hnRNPC1/C2 tetramer (C13C21) 13, 14 is known to play a role in (i) chromatin remodeling; 15 (ii) the early steps of spliceosome assembly and pre-mRNA splicing; 16, 17 and (iii) in modulating the stability, export and level of translation of bound mRNA molecules by interacting with the 5″-UTR of mRNAs and non-coding RNAs.
At equilibrium: Ψ w (cell ) = Ψ Π (bath ) + Ψ p (bath ) = Ψ Π (bath ) Osmotic potential (of a specific compartment) (notation: Ψ Π or more rarely Ψs, units MPa): this energy per unit volume corresponds to the stabilization of water molecules by interacting with solutes.
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Substitution of electronegative sulfonyl group at R3 position enhanced the binding potential of the molecule by interacting with Ser353 (Figs. 5, 6).
CD24 is mostly considered as an adhesion molecule; by interacting with p-selectin.
This is probably due to some slight restriction of lateral diffusion due to the addition of the intracellular EYFP moiety, which could slow down the whole molecule by interacting with some intracellular component.
Mammalian Rho GTPases comprise a family of intracellular signaling molecules which, by interacting with target proteins, control a variety of cellular functions such as cell adhesion, cell cycle progression, cell migration, cell morphogenesis, gene expression and actin cytoskeleton dynamics [1], [2], [3].
It is uncertain how this occurs at the molecular level, but this observation suggests that the Josephin domain may distinguish terminal vs. internal Ub-Ub linkages either as a single molecule or by interacting with other Josephin domains.
In the case of full-length fibrils, AChE might circumvent the steric overlap to interact with contiguous PrP molecules by alternately interacting with the two N-terminal PrP sites.
As such, the findings of Bonasio, Lecona et al. support models whereby RNA molecules can regulate the expression of genes, and suggest that some RNA molecules do this by interacting with SCML2A.
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