Exact(7)
This transformation had only four experimentally measured pairs of molecules but has been "amplified" using 362 predicted pairs of molecules (p-value <10−6).
It is becoming clearer that epithelial layer is not only a passive physical barrier against luminal microorganisms and toxic molecules but has a more active role in maintaining the intestinal mucosa integrity.
The idea of privileged scaffolds – that there seem to be more bioactive compounds found around some structures than others – is well established for small drug molecules, but has little significance for standalone peptide secondary structures whose adaptable shapes escape the definition of a 3D motif in the absence of a protein scaffold.
These results imply that receptor endocytosis utilizes the same molecules but has a regulatory mode that depends on the amount of ligand.
Click-mechanochemistry has been applied widely on small organic molecules but has never been employed to modify GO.
Several groups found that CTLA-4 binds to the same ligands as CD28, i.e. CD80 and CD86 molecules, but has at least a 20-fold greater affinity [ 44].
Similar(53)
Stirring during assay significantly increased the observed permeabilities for highly mobile molecules, but had minimal impact on the poorly permeable molecules.
Immortalized cell lines overexpressing mutant CFTR are typically used to screen candidate molecules but have proven to be poor predictors of clinical efficacy.
The octahedral Cu2O-Au nanocomposites have not only simultaneously served as signal amplifying molecules but have also been utilized as an ideal loading platform to immobilize a large number of electroactive substances and recognition probes.
The results indicate that the alkyl side chains have little effect on the optical properties of individual polymer molecules, but have a significant impact on optical, electrochemical, film-forming and photovoltaic properties of the polymers in the aggregated state.
In particular, triacylglycerides are well known energy storage molecules but have no known function as signaling molecules that may affect cell fate [38].
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