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These small, synthetic, homogeneous molecules bind in the GAG-binding site of proteins resulting in modulation of function.
Many small molecules bind in the T4 binding pocket of TTR and prevent its aggregation and amyloidogenesis cascade by stabilizing the native tetramer [ 27– 29].
X-ray crystal structural analysis of one of the inhibitors in complex with homoserine dehydrogenase reveals that these molecules bind in the amino acid binding region of the active site and that the phenolic hydroxyl group interacts specifically with the backbone amide of Gly175.
These small molecules bind in the TTR T4 binding pocket and kinetically stabilize the tetramer, preventing its dissociation into monomers and thus aggregation and amyloid fibril formation.
Since two ANS molecules bind in analogy to the positions of the corresponding oleate molecules, they are named ANS128 and ANS129 respectively in this study.
The two Tc molecules bind in succession, and without cooperativity, to yield TetR2 Tc2 [ 20, 37].
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These results indicate that the CYP3A4 binding pocket is large enough to accommodate up to four CBZ molecules and that the A370V and I369F mutations considerably affect the mobility of CBZ molecules bound in the binding pocket.
Measurements of 1H and 13C spin spin and spin lattice relaxations showed the presence of two kinds of EtOH molecules: besides the free EtOH expelled from the PVME mesoglobules there are also EtOH molecules bound in PVME mesoglobules.
Saliva also contains a starch-digesting enzyme called amylase (ptyalin), which initiates the process of enzymatic hydrolysis; it splits starch (a polysaccharide containing many sugar molecules bound in a continuous chain) into molecules of the double sugar maltose.
The good fire resistance characteristics of gypsum plasterboards are mainly owed to the gypsum "dehydration" process, occurring between 80 °C and 250 °C, where large quantities of energy are absorbed by evaporating water molecules, bound in the gypsum's crystal lattice.
It is known that, in many coiled-coil helix structures from soluble proteins, the backbone hydrogen bonds of α-helices are often accompanied by water molecules bound in surface grooves (see examples in PDB file 2Q12 (Zhu et al., 2007) and 3CI9 (Liu et al., 2009)).
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