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Ribozymes are small and versatile nucleic acids that can cleave RNA molecules at specific sites.
This possibility is now close to reality due to a recent discovery of the adaptive bacterial immune system, which is based on clustered regularly interspaced short palindromic repeats (CRISPR -associated proteins (CRISPR -associatedRNA to find and cut the double-stranded DNA molecules at sproteinsloCasions.
Given the similar shearing of ACT1, TRA1 and the RPL26A promoter, as described above, we asked whether chromatin structures can influence the concentration of molecules at specific loci in input sample preparation.
Another benefit of a rod-like shape is the inherent breaking of symmetry, allowing the cell to concentrate molecules at specific cellular locales.
Currently researched methods for the development of site-specific drug conjugation are based on introducing selectively reactive molecules at specific locations along the mAb.
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The screening of approximately 2000 compounds revealed four small molecules that at specific concentrations affect retinal vessel morphology but do not produce obvious changes in trunk vessels, or in the neuronal architecture of the retina.
It is also interesting to note that this study used a conventional tracer, so it is possible that much greater sensitivity could be achieved by conjugating the tracer to molecules directed at specific molecular targets.
The result derived from the ΔΔCt ×100 corresponds to percentage of methylated reference (PMR), which indicates the percentage of fully methylated molecules at a specific locus [21].
Each complex can release product molecules at the specific rate k.
The fraction of fully methylated molecules at a specific locus was represented as percentage of methylated reference (PMR).
The percentage of fully methylated molecules at a specific locus was calculated by dividing the GENE: COL2A1 ratio of a sample by the GENE: COL2A1 ratio of SssI-treated controls and multiplying by 100.
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