For instance, digestive enzymes may be secreted in inactive forms with exposure to accompanying activator molecules only occurring at precise times and locations.
These molecules enable precise targeting and cutting at a specific genomic locus to generate double-strand breaks (DSBs) followed by nonhomologous end joining (NHEJ) or homology-directed repair (HDR -mediated repair, tHDR -mediatedng prepair genome edithereby
Bendable molecules: A bundle of DNA helices (top row) can be made to bend at precise angles (the other rows) by introducing or deleting base pairs in the DNA sequence.
The ability of these enzymes to cut DNA at precise locations enabled researchers to isolate gene-containing fragments and recombine them with other molecules of DNA i.e., to clone genes.
Single-molecule, super-resolution (SR) fluorescence imaging using controllably blinking fluorescent molecules and precise localization algorithms has enabled the characterization of disease aggregates at high resolution (10 50 nm).
The detector molecules are precise enough even to show exactly where in the cell zinc molecules are.
In fact they occur at precise times in precise positions of the three-dimensional space.
He invented a pump that delivered precise doses of medicine at precise intervals.
In contrast, positioning aims at precise position estimates.
While these experimental approaches in principle are suitable for determining adhesion energy, questions remain as to the precise spatiotemporal distribution of adhesion molecules at cell contacts and the proper interpretation of cell separation experiments.
