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This complete change in the UAG meaning enabled protein synthesis with these non-natural molecules at multiple defined sites, in addition to the 20 canonical amino acids.
Besides site-specific deadenylation of the A4324 in the Sarcin/Ricin domain of rat ribosome, this protein could also release the adenine base from DNA molecules at multiple sites and from AMP, ADP, dAMP and adenosine.
The functions of miRNAs have been investigated in detail, particularly in regulating TLR-signalling pathways and innate immune responses by targeting multiple molecules at multiple levels.
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Many biogenic small molecules function at multiple levels, making it difficult and often artificial to differentiate between "metabolites", that is, compounds that are part of primary metabolism, and "secondary metabolites", that is, compounds not necessarily required for metabolic functioning.
They also extend our current view on the mechanism of action of TLR7 agonists and suggest that these molecules act at multiple levels to counter-regulate allergic airway disease.
The molecule acts at multiple sites of the angiogenic cascade.
This distribution predicts that axial staggering between neighboring myosin II molecules occurs at multiples of 98aa.
The advantages of the process are in the production of biologically active proteins, exosomes, and signaling molecules, developing a "systems therapeutic" yielding a combination of many molecules, that act at multiple targets, resulting in a synergistic therapeutic with emergent therapeutic value.
Interactions between parasite-encoded proteins and host carbohydrate molecules are essential at multiple stages in the life cycle of the malaria-causing parasite, Plasmodium falciparum, and these interactions are targets for the development of therapeutics to treat the disease.
These key molecules may be regulated at multiple levels, including transcription, protein stability, and phosphorylation.
A different single-molecule study of pausing at multiple sites did not detect backtracking at sequences that induced RNAP pausing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com