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First, the structure of the Ndc80 complex is known, which allowed us to place the donor and acceptor molecules at distinct separations spanning 10 nm.
The generation of various phosphoinositide messenger molecules at distinct locations within the cell is mediated via the specific targeting of different isoforms and splice variants of phosphoinositide kinases.
Here, we describe a method for the detection of enzymatically derived branched polyUb conjugates in which a single Ub subunit is modified by two Ub molecules at distinct lysine residues.
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CASE was applied initially to "small molecules" as distinct from biological macromolecules and biopolymers.
As a simulation technique, simulated tempering algorithm was used to obtain equilibrium conformations of the molecule at ten distinct temperatures.
Chemical modifications to the cilengitide molecule, including N-methylation at distinct positions, can modulate its biological, structural, and pharmacokinetic properties; this could enhance selectivity, particularly for the αv β3 subtype [ 77].
For each channel, a CG system in which all four PIP2 molecules were bound to the channel at distinct sites was selected for conversion.
Recent work identified small molecules that modulate the ISR pathway at distinct steps: (1) kinase inhibitors that target PERK or PKR (Jammi et al., 2003; Atkins et al., 2013); (2) an activator of HRI (Chen et al., 2011); (3) salubrinal, an inhibitor of eIF2α phosphatases (Boyce et al., 2005); and (4) ISRIB (Sidrauski et al., 2013).
The water molecule in the HY0.25 is located at distinct sites in channels.
First, Voorhees and Hegde examined precisely when the SRP binds by using shortened versions of messenger RNA molecules to trap the SRP-ribosome complex at distinct points in the translation of a membrane protein.
The existence of segregated central projection of two ON DS cell subtypes suggests that each subtype express distinct guidance molecules at an embryonic stage.
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