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Exact(14)
Peptide, any organic substance of which the molecules are structurally like those of proteins, but smaller.
How those molecules are structurally organized at MCS remains enigmatic, limiting our understanding of MCS function.
Unfortunately the SPP does not provide any guidance on how to identify or measure whether two molecules are structurally similar.
In others the molecules are structurally similar but known targets are different e.g. ethionamide (InhA), prothionamide (SahH) and nicotinamide (SahH).
Both of the new benchmarks use co-appearance in the same ChEMBL assay as an indication that two molecules are structurally similar (according to the definition in the Introduction).
However, there are many issues to address to achieve this goal, as discussed in a recent review by Sutherland et al. [12] One of the issues is that there is no obvious answer to what similarity threshold value should be used to determine whether two molecules are structurally similar.
Similar(46)
As can be seen from Figure 1, the alpha-helical fragment of protein molecules is structurally a nanotube.
Note that in this context, a "false similar" pair of molecules is structurally similar but not similar in terms of biological activity.
Furthermore, none of these currently known life-extending molecules is structurally related to the anti-aging compounds that we revealed.
In our analysis, the multiple sequences alignment with zebra mussel EGP-like genes in response to the byssogenic activities suggested that these molecules were structurally similar but not identical to each other.
Interestingly, none of the currently known life-extending molecules is structurally related to LCA and none of them was able to extend the CLS of a short-lived yeast mutant which Goldberg and colleagues used in their screen for compounds specifically targeting housekeeping longevity pathway(s).
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