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These molecules are readily detectable in human tissues and circulation.
In the resulting kymograph, the linear movements of molecules are readily visualized as bright spots moving along diagonal lines.
An enormous range of possible dyes are available, especially as the starting molecules are readily available and cheap.
Molecules are readily visualized by atomic force microscopy, opening unique opportunities to observe single polymer molecules as they move, order, and react on surfaces.
These molecules are readily taken up by cells, and they therefore provide a valuable means for drug delivery, with reports of efficient transport across the blood brain barrier in mice [5] and nuclear penetration in the human HeLa cell line [6].
The initial treatment with NaOH leads to some membrane damage, since small molecules are readily released during this incubation.
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These molecules were readily synthesized via a convergent synthetic route involving iterative palladium-mediated cross-coupling, and exhibit enhanced chemical stability, as well as resistance to metabolic inactivation via eicosanoid oxido-reductase.
In summary, a set of molecules is readily induced in T cells upon TCR signaling and provides a second wave of co-stimulation.
Although AQP-4 reactivity was still distributed over the entire astrocytic cell surface, an aggregation of AQP-4 molecules was readily detectable, which was strongly suggestive for internalization of AQP-4 by endocytosis (Fig. 4k, o, s) [ 17].
That the molecules detected by AFM represent individual dimers rather than end-to-end tetramers was determined by introduction of an HA epitope tag into the central hinge region; antibody labeling of such molecules was readily detected by AFM and showed antibodies at the position expected for the epitope tag location within a parallel dimer.
Mutational hotspots with positional mutation rates well above the rate averaged over the entire molecule are readily identified by aggregating the macro-haplogroup trees and counting the recurrent changes at each site; see [ 21] and Table 4 of [ 22].
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