Sentence examples for molecules are downregulated from inspiring English sources

Fourteen adhesion molecules and related molecules are downregulated in the VEGFδ/δ mouse.

Other molecules are downregulated in tumour tissue when compared with normal prostate tissue (Bowen et al, 2000; Xu et al, 2003).

When MHC class I molecules are downregulated or absent, NK cells are released from the inhibitory influence of these receptors and kill target cells more efficiently ('missing self' hypothesis) [ 14].

It is tempting to suggest that, as angiogenesis is a feature of early-to-mid stage tumourigenesis, perhaps proangiogenic molecules are downregulated in established poorly differentiated tumours such as Gleason score 7 10 PCa.

Because PP2A has been described as a negative regulator for the mitogen-activated protein kinases extracellular signal-related kinase and c-Jun N-terminal kinase, and these molecules are downregulated after CTLA-4 engagement [ 49], PP2A might serve as the mediator for these downstream effects of CTLA-4.

We observed that both these molecules were downregulated by hUCBSC treatments in co-cultures.

Quantification confirmed that these molecules were downregulated in tumor brains treated with hUCBSC.

Although small regulatory molecules were downregulated or upregulated, their target mRNAs might show consistent or inconsistent dysregulation patterns.

Several studies have shown that expression of HLA class I molecules and B7 costimulatory molecules is downregulated in HCC tissue and HCC cell lines.

The most striking difference amongst the HIGH and LOW groups was that expression of antigen-presenting molecules was downregulated in the former (Additional file 4A).

Expression by DCs of costimulatory molecules is downregulated, and DCs exhibit impaired cytokine production and a reduced ability to stimulate T cells.