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Renal accumulation and abnormal regulation of extracellular matrix molecules are both characteristics of CKD and can be directly linked to impaired kidney function.
Deamidated-isomerized molecules are both structurally and functionally altered.
Human MHC class I molecules are both polygenic and highly polymorphic [4].
We can also construct molecule-molecule links if two small molecules are both used to treat the same disease.
The initial success of DARTS with 1D gels is likely due to two factors: the targets of the chosen small molecules are both high abundance proteins, and neither protein is extremely sensitive or resistant to the proteases used (62).
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Then, we show experimentally that the input number of molecules and the measured output number of molecules were both consistent through a model measurement system that fulfills the two requirements.
Since experimental determination of IC50 values for a vast number of molecules is both time consuming and expensive, computational approaches are employed.
Thus, these molecules were both able to suppress and to promote tumor progression [ 8].
Formulating descriptions for how electrons and protons move within and between molecules is both appealing and timely.
Collagen type I accumulation in fibrosis, as many other ECM molecules, is both due to decreased degradation and elevated synthesis [ 14, 69].
BH12700 (VceA, a multidrug resistance gene), and BH13260 (VirB2, a T4SS molecule), are both differentially reactive between genotypes I and II, and could facilitate an understanding of the differences between the two types.
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