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In other words, the initial high temperature stress signals must be transmitted by some signaling molecules and trigger downstream signaling processes and transcription controls, which in-turn activate stress-responsive mechanisms to reestablish homeostasis and protect and repair damaged proteins and membranes.
Various receptors on cell surface recognize specific extracellular molecules and trigger signal transduction altering gene expression in the nucleus.
Strikingly, most of the gluten peptides implicated in CD require modification by the enzyme tissue transglutaminase before they can bind to the disease-predisposing HLA-DQ molecules and trigger T cell responses [2] [5].
Besides, antibody fragments appear to be more appropriate for TSE treatment than full antibodies, since bivalent anti-PrP antibodies have been shown to cross-link PrPC molecules and trigger neuronal apoptosis in certain neuronal populations [56].
Here we show that HSP60 fulfils the three defining properties of a T-cell ergotope: activated T cells express HSP60; HSP60 epitopes are presented by T-cell MHC molecules and trigger specific anti-ergotypic T cells; and the HSP60-specific anti-ergotypic T cells can down-regulate pro-inflammatory effects of effector T cells in vitro and in vivo.
EGCG can bind to target molecules and trigger signaling cascades, many of which are interconnected.
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Such moderate heating also increases the diffusion rate of reactive molecules and triggers reactions among them in the OR mantle.
Then, gp42 on EBV interacts with MHC class II molecules and triggers fusion with the host membrane.
Killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) loci are both highly polymorphic, and some HLA class I molecules bind and trigger cell-surface receptors specified by KIR genes.
CD134-engagement by CD134L recruits TNFR-associated factors (TRAFs) to the cytoplasmic tail of the molecule and triggers an NF-κB1-dependent signalling pathway; if native Env acts as a CD134 agonist, viral attachment to CD134 may promote the expansion and survival of the very target cells required for FIV replication.
The commands direct the movement of the waldo, to pick up, rotate, and drop atoms and molecules, and to trigger reactor events such as chemical bond formation.
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