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The involvement of various chemokines, as well as the expression of cellular adhesion molecules and tight junction proteins has been described [14].
The loss of adhesion molecules and tight junctions alongside increased expression of mesenchymal cell markers allows migration into tissues.
A total of 22 different mRNAs for immune effector molecules and tight junction proteins were used as indicators of ongoing mucosal inflammation.
Cell adhesion molecules and tight junction proteins on cell surfaces (eg, β1 integrins and E-cadherin) maintain cell cell contacts and contact with the ECM.
Expression levels of mRNAs for 22 different immune effector molecules and tight junction proteins were determined by quantitative reverse transcriptase (RT -PCR.
In the following text, we report the results according to functional molecular classes, i.e., proinflammatory and downregulatory cytokines, chemokines, natural killer (NK) receptors, and MHC class I molecules, and tight junction proteins.
Similar(52)
We noted that genes with their expression changes correlated with cancer grades are highly enriched among secreted or membrane proteins (P-value <0.05), which participate in multiple signaling pathways such as ErbB, FAS, NOD-like receptor, PPAR and Wnt signaling, as well as cell adhesion molecules (CAMs) and tight junctions.
Changes in the structural and contractile genes associated with the actin cytoskeleton, focal adhesion molecules, adherens and tight junctions represent a large subset of genes that are over-expressed in pregnant, compared to non-pregnant, human myometrium [ 18].
Cells undergoing EMT lose their epithelial morphology, reorganize their cytoskeleton, and acquire a motile phenotype through the up- and downregulation of several molecules including tight and adherent junctions proteins and mesenchymal markers [ 31].
Cell-cell adhesion molecules (including E-cadherins and tight junction proteins such as ZO-1 (zona occludens 1)) play a pivotal role in maintaining normal breast epithelial architecture.
Besides targeting T cells, DP acts on endothelial cells by altering gene expression of adhesion, chemotactic and tight junction molecules in vitro and in vivo.
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