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Hydrogen constitutes nearly half of all atoms in protein molecules and plays an important role in controlling the folding kinetics and in stabilizing the native state through hydrophobic interactions and hydrogen bonding [1], [2], [3], [4].

IL-8 is one of the most neutrophil chemoattractant molecules and plays a very important role in pathogenesis mediated by neutrophils in RA [ 5, 37].

Selectin E is a member of the selectin family of cell adhesion molecules and plays a central role in adhesion of leukocytes to the endothelium [ 25].

The intracellular domain, whose structure is not yet known, is responsible for post-translational modulation by intracellular molecules and plays a role in channel conductance.

Steinbaugh et al.'s findings show that SKN-1 can be activated by fat molecules and plays a direct role in controlling the amount of fat stored in the body of the worms.

NF-kB is previously reported as a transcription factor, which controls expression of several oncogenes, growth factors and cell adhesion molecules and plays a key role in carcinogenesis [ 42- 44].

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The result, the Orion, launched in 2007, and was used to classify drug molecules and play Sodoku.

QDs made of different materials coupled with biological molecules can replace a lot of fluorescent dye molecules and play a significant role in cell biology research.

Lipocalins transport small hydrophobic molecules, and play important roles in various biological processes such as development and stress responses.

Finally, cells ranging from native skin cells to innate and adaptive immune cells produce cytokines and other molecules and play specific roles in lesion formation and perpetuation.

As result many plant peptides and proteins evolved as signaling molecules and play a key role in homeostasis, defense, growth, differentiation, and senescence.

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