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After a preliminary evaluation of more than 100 different nanoparticle drug formulations, Langer and his colleagues settled on a design containing 100-nanometer particles made from a combination of a biodegradable polymer known as PLA and a coating of PEG, another polymer that readily binds water molecules and helps hide the particles from the immune system.
This prevents disrupting the structure of the protein molecules and helps, at the same time, to neutralize the acidity generated by the hydrolytic degradation of the PLGA [ 113].
Because the phosphorylation of S403 likely enhances the affinity to ubiquitinated molecules and helps degrade them by autophagy, it is possible that P-S403 signals physiologically occur, but may be relatively undetectable due to rapid self-degradation.
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It turned out that I loved being a chemist, creating molecules and helping to discover treatments for diseases.
The experimental approaches here used could lead to a better design of new therapeutic molecules and help to elucidate molecular mechanisms of new anticancer drugs.
These matrices contain macromolecular assemblies rich in carbohydrate moieties and protect the epithelium from mechanical damage, are barriers against microorganisms and toxic molecules, and help to keep the epithelial surface hydrated and lubricated.
This approach effectively deleted certain candidate edges between signaling molecules, and helped to remove redundant variables to obtain a concise model in the final step.
Proteins called receptors, which are embedded in the surface of the cilia, bind to these molecules and help to transmit information about these signals into the cell.
To create this glucose-responsive insulin, the researchers first added a long chain of fatty molecules, which dangles from the insulin molecule and helps it circulate in the bloodstream longer.
Information about electron density distribution in a molecule is very useful, because it gives us an insight into the chemical behavior of the molecule and helps us to understand its reactivity.
Our present lipid/peptide surfactant membrane model provides the basis to learn more about possible effects of active molecules in biomembranes and helps to understand structural transitions that occur within biological cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com