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In experiments in mice, they disrupted these molecules and found that the brown fat cells lost their function and physically looked more like white fat cells, where the body stores excess energy.
They screened 20,000 variations of the peptide for the most promising molecules and found the most promising to be as potent as the antibacterial peptides used in the food industry to protect perishables.
Nearly half of the 29 novel inhibitors reported here are benzoic acid derivatives and related molecules, and found to be potent inhibitors of multistage glycation, AGE formation, and AGE-protein crosslinking.
They used a computer to test the evolution of drug molecules and found their predictions to be 75% correct.
Based on these rules, we also tried to understand the behaviour of new class of anti-tuberculosis molecules and found that out of 7 replication mode inhibitors (PA-824, OPC-67683, TMC207, SQ109, Thioridazine, Lineziod, PNU-100480), on an average 3 (42.8%) molecules satisfied these rules.
To investigate cellular components, we used a polyclonal antibody to detect CEA family molecules and found that there was a correlation between the level of CEA family expression and the extent of virus replication and cell killing.
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But they needed to develop new chemical strategies to make interlocking ring molecules and find a way to convert energy into work in other words, construct a molecular motor all at a size one-thousandth that of a human hair.
In addition, we investigate the velocity of the desorbed molecules and find that even for these very large particles the velocity is significantly lower than in MALDI.
Users are able to search the interaction between the signaling molecules and find that both of RGS4 and CHRM1, the muscarinic cholinergic receptor M1 for the neurotransmitter acetylcholine, regulate the activity of the Gα q-linked pathway.
In this paper, we study the inelastic contributions to the current in cross-conjugated molecules and find that while the inelastic contribution to the current is larger than for molecules without interference, the overall behavior of the molecule is still dominated by the quantum interference feature.
"We were looking for a fancy, complex organic molecule and found something simple instead," he explains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com